Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

Massimo Bonora, Mariusz R. Wieckowski, David A. Sinclair, Guido Kroemer, Paolo Pinton, Lorenzo Galluzzi

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    201 Citations (Scopus)

    Résumé

    A large body of evidence indicates that mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary efforts have been focused on the development of agents that specifically target mitochondria for the treatment of cardiovascular disease. Despite such an intensive wave of investigation, no drugs specifically conceived to modulate mitochondrial functions are currently available for the clinical management of cardiovascular disease. In this Review, we discuss the therapeutic potential of targeting mitochondria in patients with cardiovascular disease, examine the obstacles that have restrained the development of mitochondria-targeting agents thus far, and identify strategies that might empower the full clinical potential of this approach.

    langue originaleAnglais
    Pages (de - à)33-55
    Nombre de pages23
    journalNature Reviews Cardiology
    Volume16
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2019

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