Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis

on behalf of the RENAPE Network

doi:10.1007/s00428-021-03099-1

Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis

on behalf of the RENAPE Network

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

11 Citations (Scopus)

Résumé

Epithelioid mesothelioma is the most prevalent subtype of diffuse malignant peritoneal mesothelioma. The relationship between a strong adaptive immune response and a better prognosis in malignant solid tumors is widely known. Due to the low incidence of epithelioid malignant peritoneal mesothelioma (EMPM), very little is known about their immune micro-environment. We encountered several cases of tertiary lymphoid structures in EMPM in a previous study and aimed to investigate in the same series the prevalence, clinicopathological features, and the prognostic impact associated with tertiary lymphoid structures in EMPM (TLS-EMPM). Cases of EMPM, from 1995 to 2018, were retrieved from 7 French institutions from the RENAPE Network. The predictions in terms of overall survival (OS) and progression-free survival (PFS) of TLS-EMPM were analyzed. We report 52 cases of TLS-EMPM among a series of 138 cases of EMPM. TLS-EMPM was significantly associated with neoadjuvant chemotherapy, and was not a prognostic indicator for OS (p = 0.652) and PFS (p = 0.804) in our series. TLS is a component of the host immune response to EMPM significantly associated with neoadjuvant chemotherapy, but was not a predictor of prognosis for overall and progression-free survivals in this series. These findings provide another possible etiology for tertiary lymphoid structures.

langue originale	Anglais
Pages (de - à)	765-772
Nombre de pages	8
journal	Virchows Archiv
Volume	479
Numéro de publication	4
Les DOIs	https://doi.org/10.1007/s00428-021-03099-1
état	Publié - 1 oct. 2021

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10.1007/s00428-021-03099-1

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@article{7f9ddf41e73d415cb844cab37e860928,

title = "Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis",

abstract = "Epithelioid mesothelioma is the most prevalent subtype of diffuse malignant peritoneal mesothelioma. The relationship between a strong adaptive immune response and a better prognosis in malignant solid tumors is widely known. Due to the low incidence of epithelioid malignant peritoneal mesothelioma (EMPM), very little is known about their immune micro-environment. We encountered several cases of tertiary lymphoid structures in EMPM in a previous study and aimed to investigate in the same series the prevalence, clinicopathological features, and the prognostic impact associated with tertiary lymphoid structures in EMPM (TLS-EMPM). Cases of EMPM, from 1995 to 2018, were retrieved from 7 French institutions from the RENAPE Network. The predictions in terms of overall survival (OS) and progression-free survival (PFS) of TLS-EMPM were analyzed. We report 52 cases of TLS-EMPM among a series of 138 cases of EMPM. TLS-EMPM was significantly associated with neoadjuvant chemotherapy, and was not a prognostic indicator for OS (p = 0.652) and PFS (p = 0.804) in our series. TLS is a component of the host immune response to EMPM significantly associated with neoadjuvant chemotherapy, but was not a predictor of prognosis for overall and progression-free survivals in this series. These findings provide another possible etiology for tertiary lymphoid structures.",

keywords = "Biomarker, Malignant epithelioid peritoneal mesothelioma, Mesothelioma, Tertiary lymphoid structures",

author = "{on behalf of the RENAPE Network} and Nazim Benzerdjeb and Peggy Dartigues and Vahan Kepenekian and S{\'e}verine Valmary-Degano and Eliane Mery and Gerlinde Av{\'e}rous and Anne Chevallier and Laverriere, {Marie H{\'e}l{\`e}ne} and Ir{\`e}ne Villa and Olivier Harou and Sall{\'e}, {Fran{\c c}oise Galateau} and Laurent Villeneuve and Olivier Glehen and Sylvie Isaac and Juliette Hommell-Fontaine and Fr{\'e}d{\'e}ric Bibeau and Julio Abba and Karine Abboud and Mohammad Alyami and Amroun Koceila and Catherine Arvieux and Naoual Bakrin and Sandrine Barbois and Rejeb, {Houda Ben} and Bereder, {Jean Marc} and Isabelle Bonnefoy and Bonnot, {Pierre Emmanuel} and Olivier Bouche and Dominique Bouzard and C{\'e}cile Brigand and S{\'e}bastien Carr{\`e}re and Bertrand C{\'e}l{\'e}rier and C{\'e}cilia Ceribelli and Julien Coget and Thomas Courvoisier and {de Chaisemartin}, C{\'e}cile and Delhorme, {Jean Baptiste} and Anthony Dohan and Fr{\'e}d{\'e}ric Dumont and Sylvaine Durand-Fontanier and Clarisse Eveno and Gwena{\"e}l Ferron and Johan Gagniere and Alexandre Galan and Laurent Ghouti and Gilly, {Fran{\c c}ois No{\"e}l} and Laurence Gladieff and Diane Go{\'e}r{\'e} and Guilloit, {Jean Marc} and Charles Honor{\'e}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2021",

month = oct,

day = "1",

doi = "10.1007/s00428-021-03099-1",

language = "English",

volume = "479",

pages = "765--772",

journal = "Virchows Archiv",

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TY - JOUR

T1 - Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis

AU - on behalf of the RENAPE Network

AU - Benzerdjeb, Nazim

AU - Dartigues, Peggy

AU - Kepenekian, Vahan

AU - Valmary-Degano, Séverine

AU - Mery, Eliane

AU - Avérous, Gerlinde

AU - Chevallier, Anne

AU - Laverriere, Marie Hélène

AU - Villa, Irène

AU - Harou, Olivier

AU - Sallé, Françoise Galateau

AU - Villeneuve, Laurent

AU - Glehen, Olivier

AU - Isaac, Sylvie

AU - Hommell-Fontaine, Juliette

AU - Bibeau, Frédéric

AU - Abba, Julio

AU - Abboud, Karine

AU - Alyami, Mohammad

AU - Koceila, Amroun

AU - Arvieux, Catherine

AU - Bakrin, Naoual

AU - Barbois, Sandrine

AU - Rejeb, Houda Ben

AU - Bereder, Jean Marc

AU - Bonnefoy, Isabelle

AU - Bonnot, Pierre Emmanuel

AU - Bouche, Olivier

AU - Bouzard, Dominique

AU - Brigand, Cécile

AU - Carrère, Sébastien

AU - Célérier, Bertrand

AU - Ceribelli, Cécilia

AU - Coget, Julien

AU - Courvoisier, Thomas

AU - de Chaisemartin, Cécile

AU - Delhorme, Jean Baptiste

AU - Dohan, Anthony

AU - Dumont, Frédéric

AU - Durand-Fontanier, Sylvaine

AU - Eveno, Clarisse

AU - Ferron, Gwenaël

AU - Gagniere, Johan

AU - Galan, Alexandre

AU - Ghouti, Laurent

AU - Gilly, François Noël

AU - Gladieff, Laurence

AU - Goéré, Diane

AU - Guilloit, Jean Marc

AU - Honoré, Charles

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Epithelioid mesothelioma is the most prevalent subtype of diffuse malignant peritoneal mesothelioma. The relationship between a strong adaptive immune response and a better prognosis in malignant solid tumors is widely known. Due to the low incidence of epithelioid malignant peritoneal mesothelioma (EMPM), very little is known about their immune micro-environment. We encountered several cases of tertiary lymphoid structures in EMPM in a previous study and aimed to investigate in the same series the prevalence, clinicopathological features, and the prognostic impact associated with tertiary lymphoid structures in EMPM (TLS-EMPM). Cases of EMPM, from 1995 to 2018, were retrieved from 7 French institutions from the RENAPE Network. The predictions in terms of overall survival (OS) and progression-free survival (PFS) of TLS-EMPM were analyzed. We report 52 cases of TLS-EMPM among a series of 138 cases of EMPM. TLS-EMPM was significantly associated with neoadjuvant chemotherapy, and was not a prognostic indicator for OS (p = 0.652) and PFS (p = 0.804) in our series. TLS is a component of the host immune response to EMPM significantly associated with neoadjuvant chemotherapy, but was not a predictor of prognosis for overall and progression-free survivals in this series. These findings provide another possible etiology for tertiary lymphoid structures.

AB - Epithelioid mesothelioma is the most prevalent subtype of diffuse malignant peritoneal mesothelioma. The relationship between a strong adaptive immune response and a better prognosis in malignant solid tumors is widely known. Due to the low incidence of epithelioid malignant peritoneal mesothelioma (EMPM), very little is known about their immune micro-environment. We encountered several cases of tertiary lymphoid structures in EMPM in a previous study and aimed to investigate in the same series the prevalence, clinicopathological features, and the prognostic impact associated with tertiary lymphoid structures in EMPM (TLS-EMPM). Cases of EMPM, from 1995 to 2018, were retrieved from 7 French institutions from the RENAPE Network. The predictions in terms of overall survival (OS) and progression-free survival (PFS) of TLS-EMPM were analyzed. We report 52 cases of TLS-EMPM among a series of 138 cases of EMPM. TLS-EMPM was significantly associated with neoadjuvant chemotherapy, and was not a prognostic indicator for OS (p = 0.652) and PFS (p = 0.804) in our series. TLS is a component of the host immune response to EMPM significantly associated with neoadjuvant chemotherapy, but was not a predictor of prognosis for overall and progression-free survivals in this series. These findings provide another possible etiology for tertiary lymphoid structures.

KW - Biomarker

KW - Malignant epithelioid peritoneal mesothelioma

KW - Mesothelioma

KW - Tertiary lymphoid structures

UR - http://www.scopus.com/inward/record.url?scp=85104814573&partnerID=8YFLogxK

U2 - 10.1007/s00428-021-03099-1

DO - 10.1007/s00428-021-03099-1

M3 - Article

C2 - 33855595

AN - SCOPUS:85104814573

SN - 0945-6317

VL - 479

SP - 765

EP - 772

JO - Virchows Archiv

JF - Virchows Archiv

IS - 4

ER -