Thérapies ciblées en oncologie pédiatrique: Nouvelle approche thérapeutique

C. Jubert, B. Geoerger, J. Grill, O. Hartmann, G. Vassal

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    A multidisciplinary therapeutic approach has led to significant increase in survival of children with cancer, however often with a high rate of severe sequela. Better understanding in tumor cell biology and transformation process allowed to describe active tyrosine kinases (mainly growth factor receptors) as a new target for cancer treatment. This review presents 2 approaches to target receptor tyrosine kinase activity: on one hand, antibodies that target the extracellular domain, the natural ligand binding site, and on the other hand, small inhibiting molecules, such as imatinib, targeted against the activated intracellular receptor tyrosine kinase. We focus on their clinical development and current application in the treatment of childhood cancer. Targeted therapies are in full rise and new perspectives are explored, such as their association to other treatment modalities and the targeting of microenvironment. This new therapeutic approach necessitates well designed clinical trials that include relevant biomarkers to evaluate its real therapeutic potential.

    Titre traduit de la contributionTargeted therapies in pediatric oncology: A new therapeutic approach?
    langue originaleFrançais
    Pages (de - à)189-194
    Nombre de pages6
    journalArchives de Pediatrie
    Volume13
    Numéro de publication2
    Les DOIs
    étatPublié - 1 janv. 2006

    mots-clés

    • Child
    • Neoplasms
    • Protein-tyrosine kinase

    Contient cette citation