The autophagic network and cancer

Marissa D. Rybstein; José Manuel Bravo-San Pedro; Guido Kroemer; Lorenzo Galluzzi

doi:10.1038/s41556-018-0042-2

The autophagic network and cancer

Marissa D. Rybstein, José Manuel Bravo-San Pedro, Guido Kroemer, Lorenzo Galluzzi

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

239 Citations (Scopus)

Résumé

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.

langue originale	Anglais
Pages (de - à)	243-251
Nombre de pages	9
journal	Nature Cell Biology
Volume	20
Numéro de publication	3
Les DOIs	https://doi.org/10.1038/s41556-018-0042-2
état	Publié - 1 mars 2018

Accès au document

10.1038/s41556-018-0042-2

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