TY - JOUR
T1 - The effects of periodontal treatment on diabetic patients
T2 - The DIAPERIO randomized controlled trial
AU - the DIAPERIO Group
AU - Vergnes, Jean Noel
AU - Canceill, Thibault
AU - Vinel, Alexia
AU - Laurencin-Dalicieux, Sara
AU - Maupas-Schwalm, Françoise
AU - Blasco-Baqué, Vincent
AU - Hanaire, Hélène
AU - Arrivé, Elise
AU - Rigalleau, Vincent
AU - Nabet, Cathy
AU - Sixou, Michel
AU - Gourdy, Pierre
AU - Monsarrat, Paul
AU - Bou, C.
AU - Sédarat, C.
AU - Dorignac, G.
AU - Botella, J. M.
AU - Gin, H.
AU - Arhainx, M. B.
AU - Augustin-Pascalis, I.
AU - Calazel-Fournier, C.
AU - Cazals, L.
AU - Combes, L.
AU - Coustols-Valat, M.
AU - Jauffret, V.
AU - Estrade, A.
AU - Hernandez, G.
AU - Labrousse-Lhermine, F.
AU - Lemozy-Cadroy, S.
AU - Lami, E.
AU - Lorenzini-Lamiche, F.
AU - Martini, J.
AU - Matta, M.
AU - Melki, V.
AU - Puech, N.
AU - Rimareix, F.
AU - Saint-Martin, F.
AU - Spiess, J.
AU - Algans, N.
AU - Gaujoux, C.
AU - Llau, M. E.
AU - Cousty, S.
AU - Jérôme, M.
AU - Kémoun, P.
AU - Loubières, P.
AU - Yan-Vergnes, W.
N1 - Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Aim: To assess whether periodontal treatment can lead to clinical, glycaemic control and quality of life improvements in metabolically unbalanced diabetic patients (type 1 or type 2) diagnosed with periodontitis. Methods: In this open-labelled randomized controlled trial, diabetic subjects (n = 91) were given “immediate” or “delayed” periodontal treatment (full-mouth non-surgical scaling and root planing, systemic antibiotics, and oral health instructions). The main outcome was the effect on glycated haemoglobin (HbA1C) and fructosamine levels. The General Oral Health Assessment Index and the SF-36 index were used to assess quality of life (QoL). Results: Periodontal health significantly improved after periodontal treatment (p < 0.001). Periodontal treatment seemed to be safe but had no significant effects on glycaemic control based on HbA1C (adjusted mean difference with a 95% confidence interval (aMD) of 0.04 [−0.16;0.24]) and fructosamine levels (aMD 5.0 [−10.2;20.2]). There was no obvious evidence of improvement in general QoL after periodontal treatment. However, there was significant improvement in oral health-related QoL (aMD 7.0 [2.4;11.6], p = 0.003). Conclusion: Although periodontal treatment showed no clinical effect on glycaemic control in this trial, important data were provided to support periodontal care among diabetic patients. Periodontal treatment is safe and improves oral health-related QoL in patients living with diabetes. ISRCTN15334496.
AB - Aim: To assess whether periodontal treatment can lead to clinical, glycaemic control and quality of life improvements in metabolically unbalanced diabetic patients (type 1 or type 2) diagnosed with periodontitis. Methods: In this open-labelled randomized controlled trial, diabetic subjects (n = 91) were given “immediate” or “delayed” periodontal treatment (full-mouth non-surgical scaling and root planing, systemic antibiotics, and oral health instructions). The main outcome was the effect on glycated haemoglobin (HbA1C) and fructosamine levels. The General Oral Health Assessment Index and the SF-36 index were used to assess quality of life (QoL). Results: Periodontal health significantly improved after periodontal treatment (p < 0.001). Periodontal treatment seemed to be safe but had no significant effects on glycaemic control based on HbA1C (adjusted mean difference with a 95% confidence interval (aMD) of 0.04 [−0.16;0.24]) and fructosamine levels (aMD 5.0 [−10.2;20.2]). There was no obvious evidence of improvement in general QoL after periodontal treatment. However, there was significant improvement in oral health-related QoL (aMD 7.0 [2.4;11.6], p = 0.003). Conclusion: Although periodontal treatment showed no clinical effect on glycaemic control in this trial, important data were provided to support periodontal care among diabetic patients. Periodontal treatment is safe and improves oral health-related QoL in patients living with diabetes. ISRCTN15334496.
KW - diabetes mellitus
KW - periodontal diseases
KW - periodontal medicine
KW - periodontitis
KW - quality of life
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85053473716&partnerID=8YFLogxK
U2 - 10.1111/jcpe.13003
DO - 10.1111/jcpe.13003
M3 - Article
C2 - 30136741
AN - SCOPUS:85053473716
SN - 0303-6979
VL - 45
SP - 1150
EP - 1163
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 10
ER -