The HLA-G low expressor genotype is associated with protection against bipolar disorder

Monojit Debnath; Marc Busson; Stéphane Jamain; Bruno Etain; Nora Hamdani; José Oliveira; Wahid Boukouaci; Kahina Amokrane; Hélène Moins-Teisserenc; Mohamed Lajnef; Djaouida Bengoufa; Alain Malafosse; Frank Bellivier; Chantal Henry; Jean Pierre Kahn; Rajagopal Krishnamoorthy; Dominique Charron; Marion Leboyer; Ryad Tamouza

doi:10.1016/j.humimm.2012.11.032

The HLA-G low expressor genotype is associated with protection against bipolar disorder

Monojit Debnath, Marc Busson, Stéphane Jamain, Bruno Etain, Nora Hamdani, José Oliveira, Wahid Boukouaci, Kahina Amokrane, Hélène Moins-Teisserenc, Mohamed Lajnef, Djaouida Bengoufa, Alain Malafosse, Frank Bellivier, Chantal Henry, Jean Pierre Kahn, Rajagopal Krishnamoorthy, Dominique Charron, Marion Leboyer, Ryad Tamouza

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

30 Citations (Scopus)

Résumé

Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=. 0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.

langue originale	Anglais
Pages (de - à)	593-597
Nombre de pages	5
journal	Human Immunology
Volume	74
Numéro de publication	5
Les DOIs	https://doi.org/10.1016/j.humimm.2012.11.032
état	Publié - 1 mai 2013
Modification externe	Oui

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10.1016/j.humimm.2012.11.032

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Debnath, M., Busson, M., Jamain, S., Etain, B., Hamdani, N., Oliveira, J., Boukouaci, W., Amokrane, K., Moins-Teisserenc, H., Lajnef, M., Bengoufa, D., Malafosse, A., Bellivier, F., Henry, C., Kahn, J. P., Krishnamoorthy, R., Charron, D., Leboyer, M., & Tamouza, R. (2013). The HLA-G low expressor genotype is associated with protection against bipolar disorder. Human Immunology, 74(5), 593-597. https://doi.org/10.1016/j.humimm.2012.11.032

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title = "The HLA-G low expressor genotype is associated with protection against bipolar disorder",

abstract = "Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=. 0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.",

author = "Monojit Debnath and Marc Busson and St{\'e}phane Jamain and Bruno Etain and Nora Hamdani and Jos{\'e} Oliveira and Wahid Boukouaci and Kahina Amokrane and H{\'e}l{\`e}ne Moins-Teisserenc and Mohamed Lajnef and Djaouida Bengoufa and Alain Malafosse and Frank Bellivier and Chantal Henry and Kahn, {Jean Pierre} and Rajagopal Krishnamoorthy and Dominique Charron and Marion Leboyer and Ryad Tamouza",

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doi = "10.1016/j.humimm.2012.11.032",

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Debnath, M, Busson, M, Jamain, S, Etain, B, Hamdani, N, Oliveira, J, Boukouaci, W, Amokrane, K, Moins-Teisserenc, H, Lajnef, M, Bengoufa, D, Malafosse, A, Bellivier, F, Henry, C, Kahn, JP, Krishnamoorthy, R, Charron, D, Leboyer, M & Tamouza, R 2013, 'The HLA-G low expressor genotype is associated with protection against bipolar disorder', Human Immunology, VOL. 74, Numéro 5, p. 593-597. https://doi.org/10.1016/j.humimm.2012.11.032

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T1 - The HLA-G low expressor genotype is associated with protection against bipolar disorder

AU - Debnath, Monojit

AU - Busson, Marc

AU - Jamain, Stéphane

AU - Etain, Bruno

AU - Hamdani, Nora

AU - Oliveira, José

AU - Boukouaci, Wahid

AU - Amokrane, Kahina

AU - Moins-Teisserenc, Hélène

AU - Lajnef, Mohamed

AU - Bengoufa, Djaouida

AU - Malafosse, Alain

AU - Bellivier, Frank

AU - Henry, Chantal

AU - Kahn, Jean Pierre

AU - Krishnamoorthy, Rajagopal

AU - Charron, Dominique

AU - Leboyer, Marion

AU - Tamouza, Ryad

PY - 2013/5/1

Y1 - 2013/5/1

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AB - Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=. 0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.

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