The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis

Marie Laure Arcangeli, Vincent Frontera, Florence Bardin, Jeanne Thomassin, Bruno Chetaille, Susanne Adams, Ralf H. Adams, Michel Aurrand-Lions

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

35 Citations (Scopus)

Résumé

Metastasis is a major clinical issue and results in poor prognosis for most cancers. The Junctional Adhesion Molecule-C (JAM-C) expressed by B16 melanoma and endothelial cells has been involved in metastasis of tumor cells through homophilic JAM-C/JAM-C trans-interactions. Here, we show that JAM-B expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with JAM-C on tumor cells. We further show that this adhesion molecular pair mediates melanoma cell adhesion to primary Lung Microvascular Endothelial Cells and that it is functional in vivo as demonstrated by the reduced metastasis of B16 cells in Jam-b deficient mice.

langue originaleAnglais
Pages (de - à)4046-4051
Nombre de pages6
journalFEBS Letters
Volume586
Numéro de publication22
Les DOIs
étatPublié - 16 nov. 2012
Modification externeOui

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