The mitochondrion in apoptosis: How Pandora's box opens

Naoufal Zamzami; Guido Kroemer

doi:10.1038/35048073

The mitochondrion in apoptosis: How Pandora's box opens

Naoufal Zamzami, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

922 Citations (Scopus)

Résumé

There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.

langue originale	Anglais
Pages (de - à)	67-71
Nombre de pages	5
journal	Nature Reviews Molecular Cell Biology
Volume	2
Numéro de publication	1
Les DOIs	https://doi.org/10.1038/35048073
état	Publié - 1 janv. 2001

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10.1038/35048073

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Contient cette citation

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