The multifaceted granulysin

Laurence Zitvogel; Kroemer Guido

doi:10.1182/blood-2010-08-299214

The multifaceted granulysin

Laurence Zitvogel, Kroemer Guido

Résultats de recherche: Contribution à un journal › !!Comment/debate

15 Citations (Scopus)

Résumé

Granulysin is a cytolytic and proinflammatory peptide contained in the cytotoxic granules of NK cells and CTL. Unexpectedly, granulysin also recruits and activates dendritic cells via TLR4/Myd88, playing the role of an immune adjuvant. Hence, in contrast to classical alarmins released by early leukocytes, granulysin is the first alarmin to be released from lymphocytes.

langue originale	Anglais
Pages (de - à)	3379-3380
Nombre de pages	2
journal	Blood
Volume	116
Numéro de publication	18
Les DOIs	https://doi.org/10.1182/blood-2010-08-299214
état	Publié - 4 nov. 2010

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10.1182/blood-2010-08-299214

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Contient cette citation

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abstract = "Granulysin is a cytolytic and proinflammatory peptide contained in the cytotoxic granules of NK cells and CTL. Unexpectedly, granulysin also recruits and activates dendritic cells via TLR4/Myd88, playing the role of an immune adjuvant. Hence, in contrast to classical alarmins released by early leukocytes, granulysin is the first alarmin to be released from lymphocytes.",

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AB - Granulysin is a cytolytic and proinflammatory peptide contained in the cytotoxic granules of NK cells and CTL. Unexpectedly, granulysin also recruits and activates dendritic cells via TLR4/Myd88, playing the role of an immune adjuvant. Hence, in contrast to classical alarmins released by early leukocytes, granulysin is the first alarmin to be released from lymphocytes.

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M3 - Comment/debate

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