The risk of second primary tumors in head and neck cancer: A systematic review

Andrés Coca-Pelaz; Juan P. Rodrigo; Carlos Suárez; Iain J. Nixon; Antti Mäkitie; Alvaro Sanabria; Miquel Quer; Primož Strojan; Carol R. Bradford; Luiz P. Kowalski; Ashok R. Shaha; Remco de Bree; Dana M. Hartl; Alessandra Rinaldo; Robert P. Takes; Alfio Ferlito

doi:10.1002/hed.26016

The risk of second primary tumors in head and neck cancer: A systematic review

Andrés Coca-Pelaz, Juan P. Rodrigo, Carlos Suárez, Iain J. Nixon, Antti Mäkitie, Alvaro Sanabria, Miquel Quer, Primož Strojan, Carol R. Bradford, Luiz P. Kowalski, Ashok R. Shaha, Remco de Bree, Dana M. Hartl, Alessandra Rinaldo, Robert P. Takes, Alfio Ferlito

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

58 Citations (Scopus)

Résumé

Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

langue originale	Anglais
Pages (de - à)	456-466
Nombre de pages	11
journal	Head and Neck
Volume	42
Numéro de publication	3
Les DOIs	https://doi.org/10.1002/hed.26016
état	Publié - 1 mars 2020

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10.1002/hed.26016

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Coca-Pelaz, A., Rodrigo, J. P., Suárez, C., Nixon, I. J., Mäkitie, A., Sanabria, A., Quer, M., Strojan, P., Bradford, C. R., Kowalski, L. P., Shaha, A. R., de Bree, R., Hartl, D. M., Rinaldo, A., Takes, R. P., & Ferlito, A. (2020). The risk of second primary tumors in head and neck cancer: A systematic review. Head and Neck, 42(3), 456-466. https://doi.org/10.1002/hed.26016

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title = "The risk of second primary tumors in head and neck cancer: A systematic review",

abstract = "Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.",

keywords = "head and neck cancer, metachronous, second primary tumor, squamous cell carcinoma, synchronous",

author = "Andr{\'e}s Coca-Pelaz and Rodrigo, {Juan P.} and Carlos Su{\'a}rez and Nixon, {Iain J.} and Antti M{\"a}kitie and Alvaro Sanabria and Miquel Quer and Primo{\v z} Strojan and Bradford, {Carol R.} and Kowalski, {Luiz P.} and Shaha, {Ashok R.} and {de Bree}, Remco and Hartl, {Dana M.} and Alessandra Rinaldo and Takes, {Robert P.} and Alfio Ferlito",

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year = "2020",

month = mar,

day = "1",

doi = "10.1002/hed.26016",

language = "English",

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T1 - The risk of second primary tumors in head and neck cancer

T2 - A systematic review

AU - Coca-Pelaz, Andrés

AU - Rodrigo, Juan P.

AU - Suárez, Carlos

AU - Nixon, Iain J.

AU - Mäkitie, Antti

AU - Sanabria, Alvaro

AU - Quer, Miquel

AU - Strojan, Primož

AU - Bradford, Carol R.

AU - Kowalski, Luiz P.

AU - Shaha, Ashok R.

AU - de Bree, Remco

AU - Hartl, Dana M.

AU - Rinaldo, Alessandra

AU - Takes, Robert P.

AU - Ferlito, Alfio

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

AB - Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

KW - head and neck cancer

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