The role of interleukin 2 in autoimmunity

Guido Kroemer; Georg Wick

doi:10.1016/0167-5699(89)90262-4

The role of interleukin 2 in autoimmunity

Guido Kroemer, Georg Wick

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

81 Citations (Scopus)

Résumé

In addition to playing a major role in physiological immune responses against foreign antigens, the interleukin 2 (IL-2)-IL-2 receptor (IL-2R) system may also be implicated in autoimmune phenomena. Initial studies on the role of IL-2 in autoimmunity indicate a deficiency in the production of this lymphokine in autoimmune disease. Here, Guido Kroemer and Georg Wick review recent data supporting the notion that an excess of endogenous or exogenous IL-2 may aggravate autoaggression by triggering autoreactive effector cells, and they speculate that IL-2 might favor the de novo development of autoimmunity by breaking autotolerance.

langue originale	Anglais
Pages (de - à)	246-251
Nombre de pages	6
journal	Immunology Today
Volume	10
Numéro de publication	7
Les DOIs	https://doi.org/10.1016/0167-5699(89)90262-4
état	Publié - 1 janv. 1989
Modification externe	Oui

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10.1016/0167-5699(89)90262-4

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abstract = "In addition to playing a major role in physiological immune responses against foreign antigens, the interleukin 2 (IL-2)-IL-2 receptor (IL-2R) system may also be implicated in autoimmune phenomena. Initial studies on the role of IL-2 in autoimmunity indicate a deficiency in the production of this lymphokine in autoimmune disease. Here, Guido Kroemer and Georg Wick review recent data supporting the notion that an excess of endogenous or exogenous IL-2 may aggravate autoaggression by triggering autoreactive effector cells, and they speculate that IL-2 might favor the de novo development of autoimmunity by breaking autotolerance.",

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