The source of MHC class I presented peptides and its implications

Sébastien Apcher, Rodrigo Prado Martins, Robin Fåhraeus

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    18 Citations (Scopus)

    Résumé

    The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides. This model has been tested and supported by scientific data. We now need new hypotheses on the physiological implications of different sources of peptides for the MHCI pathway. The aim of this overview is to give an up-to-date account of the source of antigenic peptide material for the MHCI pathway and to incorporate the more recent observations of alternative mRNA translation products into existing models of the direct and cross-presentation pathways.

    langue originaleAnglais
    Pages (de - à)117-122
    Nombre de pages6
    journalCurrent Opinion in Immunology
    Volume40
    Les DOIs
    étatPublié - 1 juin 2016

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