The Therapeutic use of human albumin in cancer patients’ management

Elissar Moujaess, May Fakhoury, Tarek Assi, Hanine Elias, Fadi El Karak, Marwan Ghosn, Joseph Kattan

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

55 Citations (Scopus)

Résumé

Human albumin (HA) has been widely used in clinical practice due to its unique physiological characteristics and pharmacokinetics. However, with the absence of clear institutional recommendations, its uncontrolled prescription remains largely controversial. An extensive review on the albumin chemistry, pharmacology, physiology and pathology was performed, and data on commercially available HA, its cost, medical usage and the related available guidelines, particularly in oncology patients were gathered. Studies assessing the appropriate use and safety of HA in cancer patients are lacking. A retrospective survey of the appropriateness of HA infusions according to the SIMTI guidelines (2009) was performed in our department. Among 53 patients who received HA infusions, only 5.7% of the indications were appropriate for HA administration. Occasionally appropriate and inappropriate indications were considered in 10% and 84.3% of the prescriptions respectively with a relatively high cost. The adoption of strict guidelines may substantially reduce the inappropriate use and the subsequent healthcare costs.

langue originaleAnglais
Pages (de - à)203-209
Nombre de pages7
journalCritical Reviews in Oncology/Hematology
Volume120
Les DOIs
étatPublié - 1 déc. 2017
Modification externeOui

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