The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs

Florence Lambolez, Marie Laure Arcangeli, Anne Marie Joret, Valérie Pasqualetto, Corinne Cordier, James P. Di Santo, Benedita Rocha, Sophie Ezine

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    72 Citations (Scopus)

    Résumé

    Thymic export of cells is believed to be restricted to mature T cells. Here we show that the thymus also exports fully committed T cell precursors that colonize primary lymphoid organs. These precursor cells exited the thymus before T cell receptor rearrangements and colonized lymphoid organs such as the thymus and the gut. Migration of the thymic T cell -committed precursors led to permanent colonization of the gut precursor compartment, improved the capacity of gut precursors to further differentiate into T cells and was sufficient for the generation of 'euthymic like' CD8αα+ intraepithelial lymphocytes. These data demonstrate a new function for the thymus in peripheral seeding with T cell precursors that become long lived after thymus export.

    langue originaleAnglais
    Pages (de - à)76-82
    Nombre de pages7
    journalNature Immunology
    Volume7
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2006

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