Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Rodrigo Nalio Ramos; Yoann Missolo-Koussou; Yohan Gerber-Ferder; Christian P. Bromley; Mattia Bugatti; Nicolas Gonzalo Núñez; Jimena Tosello Boari; Wilfrid Richer; Laurie Menger; Jordan Denizeau; Christine Sedlik; Pamela Caudana; Fiorella Kotsias; Leticia L. Niborski; Sophie Viel; Mylène Bohec; Sonia Lameiras; Sylvain Baulande; Laëtitia Lesage; André Nicolas; Didier Meseure; Anne Vincent-Salomon; Fabien Reyal; Charles Antoine Dutertre; Florent Ginhoux; Lene Vimeux; Emmanuel Donnadieu; Bénédicte Buttard; Jérôme Galon; Santiago Zelenay; William Vermi; Pierre Guermonprez; Eliane Piaggio; Julie Helft

doi:10.1016/j.cell.2022.02.021

Tissue-resident FOLR2⁺ macrophages associate with CD8⁺ T cell infiltration in human breast cancer

Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Yohan Gerber-Ferder, Christian P. Bromley, Mattia Bugatti, Nicolas Gonzalo Núñez, Jimena Tosello Boari, Wilfrid Richer, Laurie Menger, Jordan Denizeau, Christine Sedlik, Pamela Caudana, Fiorella Kotsias, Leticia L. Niborski, Sophie Viel, Mylène Bohec, Sonia Lameiras, Sylvain Baulande, Laëtitia Lesage, André NicolasDidier Meseure, Anne Vincent-Salomon, Fabien Reyal, Charles Antoine Dutertre, Florent Ginhoux, Lene Vimeux, Emmanuel Donnadieu, Bénédicte Buttard, Jérôme Galon, Santiago Zelenay, William Vermi, Pierre Guermonprez, Eliane Piaggio, Julie Helft

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

226 Citations (Scopus)

Résumé

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2⁺ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2⁺ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8⁺ T cells. FOLR2⁺ macrophages efficiently prime effector CD8⁺ T cells ex vivo. The density of FOLR2⁺ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.

langue originale	Anglais
Pages (de - à)	1189-1207.e25
journal	Cell
Volume	185
Numéro de publication	7
Les DOIs	https://doi.org/10.1016/j.cell.2022.02.021
état	Publié - 31 mars 2022

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10.1016/j.cell.2022.02.021

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Nalio Ramos, R., Missolo-Koussou, Y., Gerber-Ferder, Y., Bromley, C. P., Bugatti, M., Núñez, N. G., Tosello Boari, J., Richer, W., Menger, L., Denizeau, J., Sedlik, C., Caudana, P., Kotsias, F., Niborski, L. L., Viel, S., Bohec, M., Lameiras, S., Baulande, S., Lesage, L., ... Helft, J. (2022). Tissue-resident FOLR2⁺ macrophages associate with CD8⁺ T cell infiltration in human breast cancer. Cell, 185(7), 1189-1207.e25. https://doi.org/10.1016/j.cell.2022.02.021

@article{891bb7d0dd9a4266877aed27285c5323,

title = "Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer",

abstract = "Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.",

keywords = "CD8 T lymphocytes, FOLR2, TREM2, breast cancer, single-cell RNA sequencing, tissue-resident macrophages",

author = "{Nalio Ramos}, Rodrigo and Yoann Missolo-Koussou and Yohan Gerber-Ferder and Bromley, {Christian P.} and Mattia Bugatti and N{\'u}{\~n}ez, {Nicolas Gonzalo} and {Tosello Boari}, Jimena and Wilfrid Richer and Laurie Menger and Jordan Denizeau and Christine Sedlik and Pamela Caudana and Fiorella Kotsias and Niborski, {Leticia L.} and Sophie Viel and Myl{\`e}ne Bohec and Sonia Lameiras and Sylvain Baulande and La{\"e}titia Lesage and Andr{\'e} Nicolas and Didier Meseure and Anne Vincent-Salomon and Fabien Reyal and Dutertre, {Charles Antoine} and Florent Ginhoux and Lene Vimeux and Emmanuel Donnadieu and B{\'e}n{\'e}dicte Buttard and J{\'e}r{\^o}me Galon and Santiago Zelenay and William Vermi and Pierre Guermonprez and Eliane Piaggio and Julie Helft",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = mar,

day = "31",

doi = "10.1016/j.cell.2022.02.021",

language = "English",

volume = "185",

pages = "1189--1207.e25",

journal = "Cell",

issn = "0092-8674",

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Nalio Ramos, R, Missolo-Koussou, Y, Gerber-Ferder, Y, Bromley, CP, Bugatti, M, Núñez, NG, Tosello Boari, J, Richer, W, Menger, L, Denizeau, J, Sedlik, C, Caudana, P, Kotsias, F, Niborski, LL, Viel, S, Bohec, M, Lameiras, S, Baulande, S, Lesage, L, Nicolas, A, Meseure, D, Vincent-Salomon, A, Reyal, F, Dutertre, CA, Ginhoux, F, Vimeux, L, Donnadieu, E, Buttard, B, Galon, J, Zelenay, S, Vermi, W, Guermonprez, P, Piaggio, E & Helft, J 2022, 'Tissue-resident FOLR2⁺ macrophages associate with CD8⁺ T cell infiltration in human breast cancer', Cell, VOL. 185, Numéro 7, p. 1189-1207.e25. https://doi.org/10.1016/j.cell.2022.02.021

TY - JOUR

T1 - Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

AU - Nalio Ramos, Rodrigo

AU - Missolo-Koussou, Yoann

AU - Gerber-Ferder, Yohan

AU - Bromley, Christian P.

AU - Bugatti, Mattia

AU - Núñez, Nicolas Gonzalo

AU - Tosello Boari, Jimena

AU - Richer, Wilfrid

AU - Menger, Laurie

AU - Denizeau, Jordan

AU - Sedlik, Christine

AU - Caudana, Pamela

AU - Kotsias, Fiorella

AU - Niborski, Leticia L.

AU - Viel, Sophie

AU - Bohec, Mylène

AU - Lameiras, Sonia

AU - Baulande, Sylvain

AU - Lesage, Laëtitia

AU - Nicolas, André

AU - Meseure, Didier

AU - Vincent-Salomon, Anne

AU - Reyal, Fabien

AU - Dutertre, Charles Antoine

AU - Ginhoux, Florent

AU - Vimeux, Lene

AU - Donnadieu, Emmanuel

AU - Buttard, Bénédicte

AU - Galon, Jérôme

AU - Zelenay, Santiago

AU - Vermi, William

AU - Guermonprez, Pierre

AU - Piaggio, Eliane

AU - Helft, Julie

PY - 2022/3/31

Y1 - 2022/3/31

N2 - Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.

AB - Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.

KW - CD8 T lymphocytes

KW - FOLR2

KW - TREM2

KW - breast cancer

KW - single-cell RNA sequencing

KW - tissue-resident macrophages

UR - http://www.scopus.com/inward/record.url?scp=85127105016&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2022.02.021

DO - 10.1016/j.cell.2022.02.021

M3 - Article

C2 - 35325594

AN - SCOPUS:85127105016

SN - 0092-8674

VL - 185

SP - 1189-1207.e25

JO - Cell

JF - Cell

IS - 7

ER -