Tissue-Resident Macrophage Ontogeny and Homeostasis

Florent Ginhoux, Martin Guilliams

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

1229 Citations (Scopus)

Résumé

Defining the origins and developmental pathways of tissue-resident macrophages should help refine our understanding of the role of these cells in various disease settings and enable the design of novel macrophage-targeted therapies. In recent years the long-held belief that macrophage populations in the adult are continuously replenished by monocytes from the bone marrow (BM) has been overturned with the advent of new techniques to dissect cellular ontogeny. The new paradigm suggests that several tissue-resident macrophage populations are seeded during waves of embryonic hematopoiesis and self-maintain independently of BM contribution during adulthood. However, the exact nature of the embryonic progenitors that give rise to adult tissue-resident macrophages is still debated, and the mechanisms enabling macrophage population maintenance in the adult are undefined. Here, we review the emergence of these concepts and discuss current controversies and future directions in macrophage biology.

langue originaleAnglais
Pages (de - à)439-449
Nombre de pages11
journalImmunity
Volume44
Numéro de publication3
Les DOIs
étatPublié - 15 mars 2016
Modification externeOui

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