@article{ec00d1bb44fc44919ddc7671a08e95a5,
title = "TMEM173 Drives Lethal Coagulation in Sepsis",
abstract = "Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.",
keywords = "ER stress, GSDMD, STING, TMEM173, calcium, coagulation, inflammasome, pyroptosis, sepsis, tissue factor",
author = "Hui Zhang and Ling Zeng and Min Xie and Jiao Liu and Borong Zhou and Runliu Wu and Lizhi Cao and Guido Kroemer and Haichao Wang and Billiar, {Timothy R.} and Zeh, {Herbert J.} and Rui Kang and Jianxin Jiang and Yan Yu and Daolin Tang",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = apr,
day = "8",
doi = "10.1016/j.chom.2020.02.004",
language = "English",
volume = "27",
pages = "556--570.e6",
journal = "Cell Host and Microbe",
issn = "1931-3128",
number = "4",
}