Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.tcb.2020.02.004

Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?

Lorenzo Galluzzi, Guido Kroemer

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

5 Citations (Scopus)

Résumé

Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.

langue originale	Anglais
Pages (de - à)	339-340
Nombre de pages	2
journal	Trends in Cell Biology
Volume	30
Numéro de publication	5
Les DOIs	https://doi.org/10.1016/j.tcb.2020.02.004
état	Publié - 1 mai 2020

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10.1016/j.tcb.2020.02.004

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title = "Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?",

abstract = "Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.",

keywords = "ATG5, cardiac fibrosis, chemosensitization, immunosurveillance, longevity, neurodegeneration",

author = "Lorenzo Galluzzi and Guido Kroemer",

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year = "2020",

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T2 - A Red Flag For Pharmacological Autophagy Inhibitors?

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AU - Kroemer, Guido

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N2 - Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.

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KW - ATG5

KW - cardiac fibrosis

KW - chemosensitization

KW - immunosurveillance

KW - longevity

KW - neurodegeneration

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DO - 10.1016/j.tcb.2020.02.004

M3 - Short survey

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JO - Trends in Cell Biology

JF - Trends in Cell Biology

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