Translesion synthesis: Y-family polymerases and the polymerase switch

Alan R. Lehmann, Atsuko Niimi, Tomoo Ogi, Stephanie Brown, Simone Sabbioneda, Jonathan F. Wing, Patricia L. Kannouche, Catherine M. Green

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    330 Citations (Scopus)

    Résumé

    Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks.

    langue originaleAnglais
    Pages (de - à)891-899
    Nombre de pages9
    journalDNA Repair
    Volume6
    Numéro de publication7
    Les DOIs
    étatPublié - 1 juil. 2007

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