Trial watch: Toll-like receptor ligands in cancer therapy

Julie Le Naour, Guido Kroemer

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

16 Citations (Scopus)

Résumé

Accumulating evidence indicates that Toll-like receptor (TLR) agonists proficiently (re)instore cancer immunosurveillance as immunological adjuvants. So far, three TLR agonists have been approved by regulatory agencies for use in oncological applications. Additionally, these immunotherapeutics have been extensively investigated over the past few years. Multiple clinical trials are currently evaluating the combination of TLR agonists with chemotherapy, radiotherapy, or different immunotherapies. Moreover, antibodies targeting tumor-enriched surface proteins that have been conjugated to TLR agonists are being developed to stimulate anticancer immune responses specifically within the tumor microenvironment. Solid preclinical and translational results support the favorable immune-activating effects of TLR agonists. Here, we summarize recent preclinical and clinical advances in the development of TLR agonists for anticancer immunotherapy.

langue originaleAnglais
Numéro d'article2180237
journalOncoImmunology
Volume12
Numéro de publication1
Les DOIs
étatPublié - 1 janv. 2023
Modification externeOui

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