TRK inhibition in soft tissue sarcomas: A comprehensive review

Tarek Assi, Elie Rassy, Hussein Nassereddine, Fadi Farhat, Fadi El Karak, Joseph Kattan, Marwan Ghosn

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

11 Citations (Scopus)

Résumé

Soft-tissue sarcomas (STS) are a group of rare mesenchymal tumors that constitutes ∼1% of all solid tumors. It remains a rare tumor which lacks effective treatment options. Precision oncology may be of interest in this regard by identifying potential targets for emerging novel therapies. Neurotrophic receptor tyrosine kinase (NTRK) fusions are rare oncogenic driver mutations found in a broad range of common and rare tumor subtypes including STS. The recent approvals of NTRK inhibitors (larotrectinib and entrectinib) represent new therapeutic options in the drug armamentarium especially valuable in advanced STS given the paucity of treatment options and the generally poor prognosis of these tumors. We review the methods used to detect NTRK fusions in STS with focus on incidence, diagnosis and management of these rare and intriguing oncogenic targets.

langue originaleAnglais
Pages (de - à)73-84
Nombre de pages12
journalSeminars in Oncology
Volume47
Numéro de publication1
Les DOIs
étatPublié - 1 févr. 2020
Modification externeOui

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