Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

Sherene Loi; Roberto Salgado; Sylvia Adams; Giancarlo Pruneri; Prudence A. Francis; Magali Lacroix-Triki; Heikki Joensuu; Maria Vittoria Dieci; Sunil Badve; Sandra Demaria; Robert Gray; Elisabetta Munzone; Damien Drubay; Jerome Lemonnier; Christos Sotiriou; Pirkko Liisa Kellokumpu-Lehtinen; Andrea Vingiani; Kathryn Gray; Fabrice André; Carsten Denkert; Martine Piccart; Elvire Roblin; Stefan Michiels

doi:10.1038/s41523-021-00362-1

Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A. Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice André, Carsten DenkertMartine Piccart, Elvire Roblin, Stefan Michiels

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

The importance of integrating biomarkers into the TNM staging has been emphasized in the 8^th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8^th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.

langue originale	Anglais
Numéro d'article	3
journal	npj Breast Cancer
Volume	8
Numéro de publication	1
Les DOIs	https://doi.org/10.1038/s41523-021-00362-1
état	Publié - 1 déc. 2022

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10.1038/s41523-021-00362-1

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Contient cette citation

Loi, S., Salgado, R., Adams, S., Pruneri, G., Francis, P. A., Lacroix-Triki, M., Joensuu, H., Dieci, M. V., Badve, S., Demaria, S., Gray, R., Munzone, E., Drubay, D., Lemonnier, J., Sotiriou, C., Kellokumpu-Lehtinen, P. L., Vingiani, A., Gray, K., André, F., ... Michiels, S. (2022). Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer. npj Breast Cancer, 8(1), Article 3. https://doi.org/10.1038/s41523-021-00362-1

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title = "Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer",

abstract = "The importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.",

author = "Sherene Loi and Roberto Salgado and Sylvia Adams and Giancarlo Pruneri and Francis, {Prudence A.} and Magali Lacroix-Triki and Heikki Joensuu and Dieci, {Maria Vittoria} and Sunil Badve and Sandra Demaria and Robert Gray and Elisabetta Munzone and Damien Drubay and Jerome Lemonnier and Christos Sotiriou and Kellokumpu-Lehtinen, {Pirkko Liisa} and Andrea Vingiani and Kathryn Gray and Fabrice Andr{\'e} and Carsten Denkert and Martine Piccart and Elvire Roblin and Stefan Michiels",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

day = "1",

doi = "10.1038/s41523-021-00362-1",

language = "English",

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Loi, S, Salgado, R, Adams, S, Pruneri, G, Francis, PA, Lacroix-Triki, M, Joensuu, H, Dieci, MV, Badve, S, Demaria, S, Gray, R, Munzone, E, Drubay, D, Lemonnier, J, Sotiriou, C, Kellokumpu-Lehtinen, PL, Vingiani, A, Gray, K, André, F, Denkert, C, Piccart, M, Roblin, E & Michiels, S 2022, 'Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer', npj Breast Cancer, VOL. 8, Numéro 1, 3. https://doi.org/10.1038/s41523-021-00362-1

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T1 - Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

AU - Loi, Sherene

AU - Salgado, Roberto

AU - Adams, Sylvia

AU - Pruneri, Giancarlo

AU - Francis, Prudence A.

AU - Lacroix-Triki, Magali

AU - Joensuu, Heikki

AU - Dieci, Maria Vittoria

AU - Badve, Sunil

AU - Demaria, Sandra

AU - Gray, Robert

AU - Munzone, Elisabetta

AU - Drubay, Damien

AU - Lemonnier, Jerome

AU - Sotiriou, Christos

AU - Kellokumpu-Lehtinen, Pirkko Liisa

AU - Vingiani, Andrea

AU - Gray, Kathryn

AU - André, Fabrice

AU - Denkert, Carsten

AU - Piccart, Martine

AU - Roblin, Elvire

AU - Michiels, Stefan

PY - 2022/12/1

Y1 - 2022/12/1

N2 - The importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.

AB - The importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.

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