Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms

Eric Baudin; Aimee R. Hayes; Jean Yves Scoazec; Pier Luigi Filosso; Eric Lim; Gregory Kaltsas; Andrea Frilling; Jie Chen; Beata Kos-Kudła; Vera Gorbunova; Bertram Wiedenmann; Els Nieveen Van Dijkum; Jaroslaw B. Cwikła; Jenny Falkerby; Juan W. Valle; Matthew H. Kulke; Martyn E. Caplin

doi:10.1159/000493980

Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms

Eric Baudin, Aimee R. Hayes, Jean Yves Scoazec, Pier Luigi Filosso, Eric Lim, Gregory Kaltsas, Andrea Frilling, Jie Chen, Beata Kos-Kudła, Vera Gorbunova, Bertram Wiedenmann, Els Nieveen Van Dijkum, Jaroslaw B. Cwikła, Jenny Falkerby, Juan W. Valle, Matthew H. Kulke, Martyn E. Caplin

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

17 Citations (Scopus)

Résumé

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- A nd intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

langue originale	Anglais
Pages (de - à)	7-17
Nombre de pages	11
journal	Neuroendocrinology
Volume	108
Numéro de publication	1
Les DOIs	https://doi.org/10.1159/000493980
état	Publié - 1 janv. 2019

Accès au document

10.1159/000493980

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

Baudin, E., Hayes, A. R., Scoazec, J. Y., Filosso, P. L., Lim, E., Kaltsas, G., Frilling, A., Chen, J., Kos-Kudła, B., Gorbunova, V., Wiedenmann, B., Nieveen Van Dijkum, E., Cwikła, J. B., Falkerby, J., Valle, J. W., Kulke, M. H., & Caplin, M. E. (2019). Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms. Neuroendocrinology, 108(1), 7-17. https://doi.org/10.1159/000493980

@article{1d8389030e14422992f566c84a4ffa3b,

title = "Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms",

abstract = "Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- A nd intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.",

keywords = "Bronchial carcinoid tumours, NET, Neuroendocrine neoplasms, Pulmonary carcinoids",

author = "Eric Baudin and Hayes, {Aimee R.} and Scoazec, {Jean Yves} and Filosso, {Pier Luigi} and Eric Lim and Gregory Kaltsas and Andrea Frilling and Jie Chen and Beata Kos-Kud{\l}a and Vera Gorbunova and Bertram Wiedenmann and {Nieveen Van Dijkum}, Els and Cwik{\l}a, {Jaroslaw B.} and Jenny Falkerby and Valle, {Juan W.} and Kulke, {Matthew H.} and Caplin, {Martyn E.}",

year = "2019",

month = jan,

day = "1",

doi = "10.1159/000493980",

language = "English",

volume = "108",

pages = "7--17",

journal = "Neuroendocrinology",

issn = "0028-3835",

number = "1",

}

Baudin, E, Hayes, AR, Scoazec, JY, Filosso, PL, Lim, E, Kaltsas, G, Frilling, A, Chen, J, Kos-Kudła, B, Gorbunova, V, Wiedenmann, B, Nieveen Van Dijkum, E, Cwikła, JB, Falkerby, J, Valle, JW, Kulke, MH & Caplin, ME 2019, 'Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms', Neuroendocrinology, VOL. 108, Numéro 1, p. 7-17. https://doi.org/10.1159/000493980

TY - JOUR

T1 - Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms

AU - Baudin, Eric

AU - Hayes, Aimee R.

AU - Scoazec, Jean Yves

AU - Filosso, Pier Luigi

AU - Lim, Eric

AU - Kaltsas, Gregory

AU - Frilling, Andrea

AU - Chen, Jie

AU - Kos-Kudła, Beata

AU - Gorbunova, Vera

AU - Wiedenmann, Bertram

AU - Nieveen Van Dijkum, Els

AU - Cwikła, Jaroslaw B.

AU - Falkerby, Jenny

AU - Valle, Juan W.

AU - Kulke, Matthew H.

AU - Caplin, Martyn E.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- A nd intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

AB - Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- A nd intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

KW - Bronchial carcinoid tumours

KW - NET

KW - Neuroendocrine neoplasms

KW - Pulmonary carcinoids

UR - http://www.scopus.com/inward/record.url?scp=85058145845&partnerID=8YFLogxK

U2 - 10.1159/000493980

DO - 10.1159/000493980

M3 - Article

C2 - 30248673

AN - SCOPUS:85058145845

SN - 0028-3835

VL - 108

SP - 7

EP - 17

JO - Neuroendocrinology

JF - Neuroendocrinology

IS - 1

ER -