TY - JOUR
T1 - Using targeted therapies at the end of life
AU - Delaye, Matthieu
AU - Scotte, Florian
AU - Voisin-Saltiel, Sabine
AU - Pavliuc, Elena
AU - Vigouret-Viant, Laurence
AU - Dauchy, Sarah
AU - Mateus, Christine
N1 - Publisher Copyright:
©
PY - 2022/9/1
Y1 - 2022/9/1
N2 - The prescription of chemotherapy during the last weeks of a patient's life is a recognised criterion of decreasing quality of life but also survival. Targeted therapies have a particular efficiency and tolerance profile raising the question of their use in a palliative setting. Two patients were treated for a melanoma, at terminal stage, with poor efficiency of the symptomatic treatments. We introduced targeted therapies, which was previous treatments used in both patients.The evolution and benefits of the treatment was very different in our two patients and make us discuss the interest of targeted therapies in an end-of-life context and propose criteria for their maintenance or introduction in this indication. This discussion requires close collaboration between oncologists and palliative physicians and a very clear information given to patients and their relatives.
AB - The prescription of chemotherapy during the last weeks of a patient's life is a recognised criterion of decreasing quality of life but also survival. Targeted therapies have a particular efficiency and tolerance profile raising the question of their use in a palliative setting. Two patients were treated for a melanoma, at terminal stage, with poor efficiency of the symptomatic treatments. We introduced targeted therapies, which was previous treatments used in both patients.The evolution and benefits of the treatment was very different in our two patients and make us discuss the interest of targeted therapies in an end-of-life context and propose criteria for their maintenance or introduction in this indication. This discussion requires close collaboration between oncologists and palliative physicians and a very clear information given to patients and their relatives.
KW - end of life care
KW - quality of life
KW - supportive care
KW - symptoms and symptom management
UR - http://www.scopus.com/inward/record.url?scp=85092624006&partnerID=8YFLogxK
U2 - 10.1136/bmjspcare-2020-002529
DO - 10.1136/bmjspcare-2020-002529
M3 - Article
C2 - 32855229
AN - SCOPUS:85092624006
SN - 2045-435X
VL - 12
SP - 356
EP - 358
JO - BMJ Supportive and Palliative Care
JF - BMJ Supportive and Palliative Care
IS - 3
ER -