Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia

Xin Ying Su; Maryvonne Busson; Véronique Della Valle; Paola Ballerini; Nicole Dastugue; Pascaline Talmant; Adolfo A. Ferrando; Dominique Baudry-Bluteau; Serge Romana; Roland Berger; Olivier A. Bernard

doi:10.1002/gcc.20088

Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia

Xin Ying Su, Maryvonne Busson, Véronique Della Valle, Paola Ballerini, Nicole Dastugue, Pascaline Talmant, Adolfo A. Ferrando, Dominique Baudry-Bluteau, Serge Romana, Roland Berger, Olivier A. Bernard

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Résumé

Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CT1P2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements.

langue originale	Anglais
Pages (de - à)	243-249
Nombre de pages	7
journal	Genes Chromosomes and Cancer
Volume	41
Numéro de publication	3
Les DOIs	https://doi.org/10.1002/gcc.20088
état	Publié - 1 nov. 2004
Modification externe	Oui

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10.1002/gcc.20088

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title = "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia",

abstract = "Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CT1P2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements.",

author = "Su, {Xin Ying} and Maryvonne Busson and {Della Valle}, V{\'e}ronique and Paola Ballerini and Nicole Dastugue and Pascaline Talmant and Ferrando, {Adolfo A.} and Dominique Baudry-Bluteau and Serge Romana and Roland Berger and Bernard, {Olivier A.}",

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AU - Su, Xin Ying

AU - Busson, Maryvonne

AU - Della Valle, Véronique

AU - Ballerini, Paola

AU - Dastugue, Nicole

AU - Talmant, Pascaline

AU - Ferrando, Adolfo A.

AU - Baudry-Bluteau, Dominique

AU - Romana, Serge

AU - Berger, Roland

AU - Bernard, Olivier A.

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CT1P2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements.

AB - Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CT1P2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements.

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