TY - JOUR
T1 - Viral-induced Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplant
AU - Dosin, Gilles
AU - Aoun, Fouad
AU - El Rassy, Elie
AU - Assi, Tarek
AU - Lewalle, Philippe
AU - Blanc, Jeremy
AU - van Velthoven, Roland
AU - Bron, Dominique
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - The potential risk factors for viral-induced hemorrhagic cystitis in allogeneic HSCT are not well elaborated. We conducted a retrospective analysis including 64 patients who underwent allogeneic HSCT at Jules Bordet Institute. Hemorrhagic cystitis correlated to BK virus and adenovirus infection. Preventive measures for BK virus and adenovirus infections in patients undergoing allogeneic HSCT are required. Introduction Hemorrhagic cystitis (HC) is a well-recognized problem that is regularly observed after hematopoietic stem cell transplantation (HSCT). The published data does not report on the potential risk factors for the viral-induced HC that might require prophylactic treatments. Patients and Methods We conducted a retrospective analysis of all adult patients who underwent allogeneic HSCT at Jules Bordet Institute between 1992 and 2013. Our institutional protocol consists in monitoring the patient for signs and symptoms of HC on a daily basis during the initial admission for HSCT, then once weekly after discharge until 2 months thereafter. Results HC was found in 64 patients, of whom 56 (87.5%) had viral-induced HC. The median time between HSCT and HC was 39.5 days (range, 1-2766 days); the median time between detection of a viral infection and HC was 32 days (range, 0-2752 days). In multivariate analysis, HC is correlated to the infection with the BK virus (hazard ratio, 6.0; 95% confidence interval, 5.03-6.90; P = .0001) and the adenovirus (hazard ratio, 4.93; 95% confidence interval, 4.06-5.80; P = .0003). The 5-year overall survival of patients with HC was 36%. The 5-year survival rates were not statistically different between patients with or without HC (25% vs. 39%; P = .20). Conclusion The presence of the identified risk factors should prompt closer follow-up with screening tests and preventive measures for BK virus and adenovirus infections in patients undergoing HSCT.
AB - The potential risk factors for viral-induced hemorrhagic cystitis in allogeneic HSCT are not well elaborated. We conducted a retrospective analysis including 64 patients who underwent allogeneic HSCT at Jules Bordet Institute. Hemorrhagic cystitis correlated to BK virus and adenovirus infection. Preventive measures for BK virus and adenovirus infections in patients undergoing allogeneic HSCT are required. Introduction Hemorrhagic cystitis (HC) is a well-recognized problem that is regularly observed after hematopoietic stem cell transplantation (HSCT). The published data does not report on the potential risk factors for the viral-induced HC that might require prophylactic treatments. Patients and Methods We conducted a retrospective analysis of all adult patients who underwent allogeneic HSCT at Jules Bordet Institute between 1992 and 2013. Our institutional protocol consists in monitoring the patient for signs and symptoms of HC on a daily basis during the initial admission for HSCT, then once weekly after discharge until 2 months thereafter. Results HC was found in 64 patients, of whom 56 (87.5%) had viral-induced HC. The median time between HSCT and HC was 39.5 days (range, 1-2766 days); the median time between detection of a viral infection and HC was 32 days (range, 0-2752 days). In multivariate analysis, HC is correlated to the infection with the BK virus (hazard ratio, 6.0; 95% confidence interval, 5.03-6.90; P = .0001) and the adenovirus (hazard ratio, 4.93; 95% confidence interval, 4.06-5.80; P = .0003). The 5-year overall survival of patients with HC was 36%. The 5-year survival rates were not statistically different between patients with or without HC (25% vs. 39%; P = .20). Conclusion The presence of the identified risk factors should prompt closer follow-up with screening tests and preventive measures for BK virus and adenovirus infections in patients undergoing HSCT.
KW - Adenovirus
KW - Allogeneic hematopoietic stem cell transplant
KW - Cytomegalovirus
KW - Hemorrhagic cystitis
KW - Polyomavirus
UR - http://www.scopus.com/inward/record.url?scp=85019679591&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2017.05.013
DO - 10.1016/j.clml.2017.05.013
M3 - Article
C2 - 28559150
AN - SCOPUS:85019679591
SN - 2152-2650
VL - 17
SP - 438
EP - 442
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 7
ER -