Visual agnosia after treatment of a posterior fossa ependymoma in a 16-month-old girl

Virginie Kieffer-Renaux; Christine Bulteau; Jacques Grill; Christine Levy-Piebois; Dominique Couanet; Alain Pierre-Kahn; Olivier Hartmann; Chantal Kalifa

doi:10.1177/088307380101600917

Visual agnosia after treatment of a posterior fossa ependymoma in a 16-month-old girl

Virginie Kieffer-Renaux, Christine Bulteau, Jacques Grill, Christine Levy-Piebois, Dominique Couanet, Alain Pierre-Kahn, Olivier Hartmann, Chantal Kalifa

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Résumé

We present the clinical observation of a 16-month-old girl treated for a posterior fossa ependymoma who experienced severe and delayed visual dysfunction. She was initially treated by surgery and conventional chemotherapy. When she relapsed at age 3 years, the salvage treatment combined high-dose chemotherapy, second surgery, and local irradiation. At age 4 years, disturbed gait and dysarthric speech appeared rapidly, and she became unable to recognize objects and people. Computed tomography revealed bilateral calcifications in the cerebellum and temporal and occipital lobes but no relapse. The neuropsychologic evaluations revealed signs of visual agnosia and marked intellectual impairment. The role of the different treatment modalities in the pathogenesis of this unusual syndrome is discussed.

langue originale	Anglais
Pages (de - à)	698-704
Nombre de pages	7
journal	Journal of Child Neurology
Volume	16
Numéro de publication	9
Les DOIs	https://doi.org/10.1177/088307380101600917
état	Publié - 1 janv. 2001
Modification externe	Oui

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10.1177/088307380101600917

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abstract = "We present the clinical observation of a 16-month-old girl treated for a posterior fossa ependymoma who experienced severe and delayed visual dysfunction. She was initially treated by surgery and conventional chemotherapy. When she relapsed at age 3 years, the salvage treatment combined high-dose chemotherapy, second surgery, and local irradiation. At age 4 years, disturbed gait and dysarthric speech appeared rapidly, and she became unable to recognize objects and people. Computed tomography revealed bilateral calcifications in the cerebellum and temporal and occipital lobes but no relapse. The neuropsychologic evaluations revealed signs of visual agnosia and marked intellectual impairment. The role of the different treatment modalities in the pathogenesis of this unusual syndrome is discussed.",

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AU - Kieffer-Renaux, Virginie

AU - Bulteau, Christine

AU - Grill, Jacques

AU - Levy-Piebois, Christine

AU - Couanet, Dominique

AU - Pierre-Kahn, Alain

AU - Hartmann, Olivier

AU - Kalifa, Chantal

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N2 - We present the clinical observation of a 16-month-old girl treated for a posterior fossa ependymoma who experienced severe and delayed visual dysfunction. She was initially treated by surgery and conventional chemotherapy. When she relapsed at age 3 years, the salvage treatment combined high-dose chemotherapy, second surgery, and local irradiation. At age 4 years, disturbed gait and dysarthric speech appeared rapidly, and she became unable to recognize objects and people. Computed tomography revealed bilateral calcifications in the cerebellum and temporal and occipital lobes but no relapse. The neuropsychologic evaluations revealed signs of visual agnosia and marked intellectual impairment. The role of the different treatment modalities in the pathogenesis of this unusual syndrome is discussed.

AB - We present the clinical observation of a 16-month-old girl treated for a posterior fossa ependymoma who experienced severe and delayed visual dysfunction. She was initially treated by surgery and conventional chemotherapy. When she relapsed at age 3 years, the salvage treatment combined high-dose chemotherapy, second surgery, and local irradiation. At age 4 years, disturbed gait and dysarthric speech appeared rapidly, and she became unable to recognize objects and people. Computed tomography revealed bilateral calcifications in the cerebellum and temporal and occipital lobes but no relapse. The neuropsychologic evaluations revealed signs of visual agnosia and marked intellectual impairment. The role of the different treatment modalities in the pathogenesis of this unusual syndrome is discussed.

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