Welding and the risk of head and neck cancer: The ICARE study

Christine Barul, Mireille Matrat, Aviane Auguste, Julien Dugas, Loredana Radoï, Gwenn Menvielle, Joëlle Févotte, Anne Valérie Guizard, Isabelle Stücker, Danièle Luce

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

7 Citations (Scopus)

Résumé

Objective To investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study. Methods Analyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos. Results Welding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-Trend <0.01) and the weighted duration (p-Trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer. Conclusion Our findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.

langue originaleAnglais
Pages (de - à)293-300
Nombre de pages8
journalOccupational and Environmental Medicine
Volume77
Numéro de publication5
Les DOIs
étatPublié - 1 mai 2020
Modification externeOui

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