What role for AID: Mutator, or assembler of the immunoglobulin mutasome?

Claude Agnès Reynaud, Said Aoufouchi, Ahmad Faili, Jean Claude Weill

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    67 Citations (Scopus)

    Résumé

    Activation-induced cytidine deaminase (AID) has been shown to trigger three mechanisms for diversifying immunoglobulin genes - somatic hypermutation, isotype switch recombination and gene conversion - most probably by initiating cytidine deamination at the immunoglobulin locus. Although this deamination process has been shown to be potentially mutagenic by itself, most of the mutations generated in the physiological hypermutation process seem to be created through the AID-mediated assembly of a mutasome complex involving specific repair activities and error-prone DNA polymerases.

    langue originaleAnglais
    Pages (de - à)631-638
    Nombre de pages8
    journalNature Immunology
    Volume4
    Numéro de publication7
    Les DOIs
    étatPublié - 1 juil. 2003

    Contient cette citation