Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

Erika Vacchelli; Yuting Ma; Elisa E. Baracco; Laurence Zitvogel; Guido Kroemer

doi:10.1080/2162402X.2015.1118600

Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

Erika Vacchelli, Yuting Ma, Elisa E. Baracco, Laurence Zitvogel, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

15 Citations (Scopus)

Résumé

Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.

langue originale	Anglais
Numéro d'article	e1118600
journal	OncoImmunology
Volume	5
Numéro de publication	5
Les DOIs	https://doi.org/10.1080/2162402X.2015.1118600
état	Publié - 3 mai 2016

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10.1080/2162402X.2015.1118600

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title = "Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1",

abstract = "Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.",

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author = "Erika Vacchelli and Yuting Ma and Baracco, {Elisa E.} and Laurence Zitvogel and Guido Kroemer",

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AU - Zitvogel, Laurence

AU - Kroemer, Guido

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AB - Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.

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KW - Apoptosis

KW - CTL

KW - DAMPs

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